The crash happened Sunday along the Indiana Toll Road near Mishawaka.
State police were responding to a call about a vehicle driven erratically along the eastbound lanes when it turned around and headed westbound in the eastbound lanes. Police say the wrong-way driver collided with an SUV and a truck. A car also crashed.
Police say three passengers in the SUV died, including 42-year-old Denita Rice, 1-year-old Bryson Rice and 12-year-old Makayla Lanier. Police say the SUV driver and another child were taken to a hospital. Those in the SUV were from Painesville, Ohio.
Police said Monday 32-year-old Chintan Patel of South Bend, identified as the wrong-way driver, also died.